Nefazodone attenuates the behavioral and neurochemical effects of ethanol
| Autor: | Bo Söderpalm, Mia Ericson, Annelie Petersson, Peter Olausson, Alexander Kosowski, Jörgen A. Engel |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Health (social science) Dopamine Mesolimbic pathway Pharmacology Toxicology Biochemistry Nucleus Accumbens Piperazines Behavioral Neuroscience chemistry.chemical_compound Neurochemical Internal medicine medicine Animals Rats Wistar Ethanol Behavior Animal Chemistry Homovanillic Acid General Medicine Triazoles Rats Kinetics Endocrinology Neurology 3 4-Dihydroxyphenylacetic Acid Serotonin Serotonin Antagonists Nefazodone Reuptake inhibitor Extracellular Space Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Alcohol (Fayetteville, N.Y.). 15(1) |
| ISSN: | 0741-8329 |
| Popis: | This study evaluated the influence of nefazodone, a combined 5-HT 2A receptor antagonist and 5-HT reuptake inhibitor, on the behavioral and neurochemical effects of ethanol in nonselected male Wistar rats. In microdialysis experiments, ethanol (2.5 g/kg, IP) increased extracellular accumbal dopamine levels by 36% ( p = 0.0073) compared to baseline levels, and elevated the maximal DOPAC and HVA levels by 26% ( p = 0.0093) and 52% ( p = 0.0010), respectively. Nefazodone (50 mg/kg, SC) per se increased accumbal dopamine levels by 28% ( p = 0.0199), but, when injected 40 min before ethanol, reduced the ethanol-induced elevation of accumbal dopamine overflow ( p = 0.0132) and decreased the ethanol-induced HVA levels ( p = 0.0159). In an ethanol(6% v/v)/water free-choice paradigm, nefazodone (50 mg/kg, SC) decreased ethanol intake by 51% ( p = 0.0251) and preference by 22% ( p = 0.0251) in high- but not low-preferring rats from a nonselected Wistar strain. These results show that nefazodone modulates the mesolimbic dopamine system in a dopamine activity-dependent manner, and influences the neurochemical and behavioral effects of ethanol in the rat. |
| Databáze: | OpenAIRE |
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