The Function of HLA-B*13:01 Involved in the Pathomechanism of Dapsone-Induced Severe Cutaneous Adverse Reactions
| Autor: | Hua En Lee, Chih Hsun Yang, Siew Eng Choon, Shuen-Iu Hung, Ya Ching Chang, Wen-Hung Chung, Shih-Chi Su, Yang Yu Wei Lin, Chun-Bing Chen, Ming Tsan Liu, Ting Jui Chen, Wen Lang Fan, Wei-Ti Chen, Chuang Wei Wang, Chun-Wei Lu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male 0301 basic medicine Taiwan Leprostatic Agents Dermatology Dapsone Biochemistry Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Antigen Leprosy medicine Genetic predisposition Humans Cytotoxic T cell Genetic Predisposition to Disease Granulysin Molecular Biology Alleles HLA-B13 Antigen Skin Aged 80 and over business.industry Malaysia Cell Biology medicine.disease Coculture Techniques Toxic epidermal necrolysis 030104 developmental biology Drug Hypersensitivity Syndrome Immunology Female business T-Lymphocytes Cytotoxic medicine.drug |
| Zdroj: | Journal of Investigative Dermatology. 138:1546-1554 |
| ISSN: | 0022-202X |
| DOI: | 10.1016/j.jid.2018.02.004 |
| Popis: | Dapsone-induced hypersensitivity reactions may cause severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS). It has been reported that HLA-B*13:01 is strongly associated with dapsone-induced hypersensitivity reactions among leprosy patients. However, the phenotype specificity and detailed immune mechanism of HLA-B*13:01 remain unclear. We investigated the genetic predisposition, HLA-B*13:01 function, and cytotoxic T cells involved in the pathogenesis of dapsone-induced severe cutaneous adverse reactions. We enrolled patients from Taiwan and Malaysia with DRESS and maculopapular eruption with chronic inflammatory dermatoses. Our results showed that the HLA-B*13:01 allele was present in 85.7% (6/7) of patients with dapsone DRESS (odds ratio = 49.64, 95% confidence interval = 5.89–418.13; corrected P = 2.92 × 10–4) but in only 10.8% (73/677) of general population control individuals in Taiwan. The level of granulysin, the severe cutaneous adverse reaction-specific cytotoxic protein released from cytotoxic T cells, was increased in both the plasma of DRESS patients (36.14 ± 9.02 ng/ml, P |
| Databáze: | OpenAIRE |
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