Synthesis of Densely Functionalized 3a,4-Dihydro-1H-Pyrrolo[1,2-b]Pyrazoles via Base Mediated Domino Reaction of Vinyl Malononitriles with 1,2-Diaza-1,3-dienes
| Autor: | Fabio Mantellini, Giada Moscatelli, Gianfranco Favi, Orazio A. Attanasi, Aliki Paparisva, Athina Geronikaki |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Vinyl Compounds Molecular Structure Base (chemistry) Chemistry Organic Chemistry Stereoisomerism Alkenes Pyrazole Crystallography X-Ray Biochemistry Medicinal chemistry chemistry.chemical_compound Cascade reaction Atom economy Nitriles Pyrazoles Stereoselectivity Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 15:2624-2627 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol401336s |
| Popis: | A domino reaction of vinyl malononitriles (VMs) with 1,2-diaza-1,3-dienes (DDs) produce unprecedented 3a,4-dihydro-1H-pyrrolo[1,2-b]pyrazole systems in a chemo-, regio-, and stereoselective fashion. This base promoted (DIPEA) one-pot transformation involving multiple steps constructs one new C-C bond, two C-N bonds, and two new fused heterocyclic rings with total atom economy. |
| Databáze: | OpenAIRE |
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