Utilizing platelet-rich fibrin bioscaffold at the graft site improves the structure and function of mice ovarian grafts
| Autor: | Seyed Ma Shariatzadeh, Elham Shojafar, Malek Soleimani Mehranjani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
Embryology Angiogenesis medicine.medical_treatment 0206 medical engineering Biomedical Engineering Neovascularization Physiologic Ovary Apoptosis 02 engineering and technology Transplantation Autologous Fibrin Andrology 03 medical and health sciences chemistry.chemical_compound Mice Platelet-Rich Fibrin medicine Animals 030304 developmental biology 0303 health sciences biology Chemistry Histology Organ Transplantation musculoskeletal system Malondialdehyde 020601 biomedical engineering digestive system diseases Platelet-rich fibrin Autotransplantation surgical procedures operative medicine.anatomical_structure biology.protein Cytokines Female sense organs |
| Zdroj: | Regenerative medicine. 14(5) |
| ISSN: | 1746-076X |
| Popis: | Aim: The effect of platelet-rich fibrin (PRF) bioscaffold on the structure and function of mice-autotransplanted ovaries was investigated. Materials & methods: Mice were divided into three groups: control, autografted and autografted + PRF bioscaffold. Angiogenesis, ovary histology and serum biochemical factors were assessed. Results: The total volume of the ovary, the number of follicles and the level of superoxide dismutase activity, total antioxidant capacity, IL-10, progesterone and estradiol were significantly higher in the autografted + PRF bioscaffold group compared with the autografted group. In the autografted + PRF bioscaffold group, angiogenesis was accelerated and apoptosis rate, IL-6, TNF-α, malondialdehyde concentrations were significantly lower compared with the autografted group. Conclusion: PRF bioscaffold improves the structure and function of mice-autografted ovary. |
| Databáze: | OpenAIRE |
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