Arterial ischemic stroke risk factors: the International Pediatric Stroke Study
| Autor: | Mark T, Mackay, Max, Wiznitzer, Susan L, Benedict, Katherine J, Lee, Gabrielle A, Deveber, Vijeya, Ganesan, Andrew, Willan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Asia genetic structures Adolescent Logistic regression Brain Ischemia Brain ischemia Age Distribution Risk Factors medicine Prevalence Pediatric stroke Humans Cardiac disorders Child Stroke medicine.diagnostic_test Cerebral infarction business.industry Australia Infant Newborn Brain Infant Magnetic resonance imaging Cerebral Infarction South America medicine.disease Arterial Ischemic Stroke Magnetic Resonance Imaging Europe Neurology Child Preschool Female Neurology (clinical) business |
| Zdroj: | Annals of neurology. 69(1) |
| ISSN: | 1531-8249 |
| Popis: | Objective To describe presumptive risk factors (RFs) for childhood arterial ischemic stroke (AIS) and explore their relationship with presentation, age, geography, and infarct characteristics. Methods Children (29 days–18 years) were prospectively enrolled in the International Pediatric Stroke Study. Risk factors, defined conditions thought to be associated with childhood AIS, were divided into 10 categories. Chi-square tests were used to compare RFs prevalence across regions and age; logistic regression was used to determine whether RFs were associated with particular features at presentation or infarct characteristics. Results A total of 676 children were included. No identifiable RFs was present in 54 (9%). RFs in others included arteriopathies (53%), cardiac disorders (CDs) (31%), infection (24%), acute head and neck disorders (AHNDs) (23%), acute systemic conditions (ASCs) (22%), chronic systemic conditions (CSCs) (19%), prothrombotic states (PTSs) (13%), chronic head and neck disorders (CHNDs) (10%), atherosclerosis-related RFs (2%), and other (22%). Fifty-two percent had multiple RFs. There was lower prevalence of arteriopathy in Asia, lower prevalence of CSCs in Europe and Australia, higher prevalence of PTSs in Europe, and higher prevalence of ASCs in Asia and South America. Prevalence of CDs and ASCs was highest in preschoolers, arteriopathies in children 5 to 9 years old, and CHNDs were highest in children aged 10 to 14 years. Arteriopathies were associated with focal signs and ASCs, CHNDs, and AHNDs with diffuse signs. Arteriopathies, CSCs, and ASCs were associated with multiple infarcts and CDs with hemorrhagic conversion. Interpretation RFs, especially arteriopathy, are common in childhood AIS. Variations in RFs by age or geography may inform prioritization of investigations and targeted preventative strategies. Ann Neurol 2011;69:130–140. |
| Databáze: | OpenAIRE |
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