Virilizing Leydig-Sertoli cell ovarian tumor associated with endometrioid carcinoma of the endometrium in a postmenopausal patient: Case report and general considerations
| Autor: | Stefania Mariani, Salvatore Ulisse, Laura Guccione, Lucio Gnessi, Costanzo Moretti, Giuseppe Vancieri, Camillo Autore, Laura Chioma, Andrea Fabbri, Paola Di Giacinto, Elena Cicerone |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology Case Report endometrial carcinoma Androgen Excess Endometrium Settore MED/13 - Endocrinologia hyperandrogenism Ovarian tumor medicine sertoli-leydig tumor Sertoli-Leydig tumor virilization ovarian cancer endometrial cancer Gynecology lcsh:R5-920 business.industry Virilization Endometrial cancer Hyperandrogenism sertoli-leydig cell tumor General Medicine medicine.disease Menopause medicine.anatomical_structure medicine.symptom Ovarian cancer business lcsh:Medicine (General) |
| Zdroj: | Clinical Medicine Insights. Case Reports Clinical Medicine Insights: Case Reports, Vol 2012, Iss 5, Pp 149-153 (2012) Clinical Medicine Insights: Case Reports, Vol 5 (2012) |
| Popis: | Introduction Sertoli-Leydig cell tumors (SLCTs) are rare tumors mostly occurring in young women. Here we report an unusual case of a SLCT with simultaneous occurrence of endometrioid adenocarcinoma of the endometrium in a woman in menopause. Case Report A 67-year-old woman presented with progressive signs of virilization. Blood tests showed increased levels of testosterone, delta-4-androstenedione, and dehydroepiandrosterone (DHEA). DHEA-sulphate, 17β-estradiol, estrone, and sex-hormone binding globulin serum levels were within the normal range. Magnetic resonance imaging revealed a solid mass of 2.7 × 2.9 cm in the right ovary set against the background of the uterus. The patient underwent bilateral salpingo-oophoretomy with hysterectomy. The mass in the right ovary was a differentiated SLCT. Incidentally, the endometrium revealed an endometrioid adenocacinoma. Following surgical treatment the plasma androgens dropped to normal levels, and signs and symptoms of virilization improved. Conclusion SLCT should be suspected in postmenopausal women who present rapid progressive androgen excess symptoms with hyperandrogenemia. |
| Databáze: | OpenAIRE |
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