Comparison of Synovial Fluid Cytokine Levels between Traumatic Knee Injury and End-Stage Osteoarthritis
| Autor: | Nicholas Gajewski, Alison K. Klika, Wael K. Barsoum, Marcelo B. P. Siqueira, Salvatore J. Frangiamore, Carlos A. Higuera |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Knee Joint Inflammatory arthritis medicine.medical_treatment Knee Injuries Osteoarthritis Gastroenterology Proinflammatory cytokine Arthroscopy Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Synovial Fluid medicine Humans Synovial fluid Orthopedics and Sports Medicine Aged 030203 arthritis & rheumatology medicine.diagnostic_test Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin-8 Middle Aged Osteoarthritis Knee medicine.disease Arthroplasty Surgery 030104 developmental biology Cytokines Female business Body mass index |
| Zdroj: | The Journal of Knee Surgery. 30:128-133 |
| ISSN: | 1938-2480 1538-8506 |
| Popis: | Degenerative osteoarthritis (OA) has been associated with elevated synovial fluid cytokines. It is unclear whether traumatic knee injuries are a trigger to the chemical process that leads to OA. The purpose of this study was to compare the synovial fluid cytokine levels between knees undergoing arthroscopy due to a documented inciting injury and knees undergoing primary arthroplasty due to end-stage OA without a previous inciting injury. Synovial fluid samples were prospectively collected from knees undergoing arthroscopic surgeries due to ligamentous or meniscal knee injuries (knee injury group, n = 16) and primary arthroplasty due to OA (end-stage OA group, n = 14). In the knee injury group, patients had none or minimal OA and at least 30 days from the inciting injury. Exclusion criteria for both groups included inflammatory arthropathy (n = 1) and insufficient fluid for analysis (n = 1). In addition to synovial fluid cytokines, preoperative demographic, clinical, and functional data (Knee Injury and Osteoarthritis Outcome Score [KOOS]) were collected and compared between the groups. The end-stage OA group had higher age (p |
| Databáze: | OpenAIRE |
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