SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination
| Autor: | Jose Alfredo Samaniego Castruita, Uffe Vest Schneider, Sarah Mollerup, Thomas Daell Leineweber, Nina Weis, Jens Bukh, Martin Schou Pedersen, Henrik Westh |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Castruita, J A S, Schneider, U V, Mollerup, S, Leineweber, T D, Weis, N, Bukh, J, Pedersen, M S & Westh, H 2023, ' SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination ', APMIS, vol. 131, no. 3, pp. 128-132 . https://doi.org/10.1111/apm.13294 |
| DOI: | 10.1111/apm.13294 |
| Popis: | In Denmark, vaccination against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been with the Pfizer-BioNTech (BTN162b2) or the Moderna (mRNA-1273) mRNA vaccines. Patients with chronic hepatitis C virus (HCV) infection followed in our clinic received mRNA vaccinations according to the Danish roll-out vaccination plan. To monitor HCV infection, RNA was extracted from patient plasma and RNA sequencing was performed on the Illumina platform. In 10 of 108 HCV patient samples, full-length or traces of SARS-CoV-2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID-19 vaccination. Detection of mRNA vaccine sequences in blood after vaccination adds important knowledge regarding this technology and should lead to further research into the design of lipid-nanoparticles and the half-life of these and mRNA vaccines in humans. |
| Databáze: | OpenAIRE |
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