Characteristics of Hodgkin's lymphoma after infectious mononucleosis
| Autor: | Nils Rosdahl, Stephen Hamilton-Dutoit, Hans H. Storm, Morten Frisch, Mads Melbye, Jin-Song Zhang, Mette Madsen, Johan Askling, Klaus Rostgaard, Henrik Hjalgrim, Helle Bossen Konradsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Risk Herpesvirus 4 Human Mononucleosis Adolescent Denmark Population Antibodies Viral Cohort Studies immune system diseases hemic and lymphatic diseases Medicine Humans Infectious Mononucleosis Risk factor Reed-Sternberg Cells education Child Aged Sweden education.field_of_study business.industry Incidence General Medicine Middle Aged Hodgkin's lymphoma medicine.disease Hodgkin Disease Lymphoma Cohort Immunology Female Viral disease business Cohort study |
| Zdroj: | Hjalgrim, H, Askling, J, Rostgaard, K, Hamilton-Dutoit, S J, Frisch, M, Zhang, J-S, Madsen, M, Rosdahl, N, Konradsen, H B, Storm, H H & Melbye, M 2003, ' Characteristics of Hodgkin's lymphoma after infectious mononucleosis ' Briefings from the New England Journal of Medicine (Spanish Edition), vol. 349, no. 14, pp. 1324-32 . https://doi.org/10.1056/NEJMoa023141 |
| DOI: | 10.1056/NEJMoa023141 |
| Popis: | Infectious mononucleosis-related Epstein-Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear.We compared the incidence rates of Hodgkin's lymphoma in two population-based Danish cohorts of patients who were tested for infectious mononucleosis: 17,045 with serologic evidence of having had acute EBV infection, and 24,614 with no such evidence. We combined the cohort of patients who had serologically verified infectious mononucleosis with a cohort of 21,510 Swedish patients with infectious mononucleosis (combined total, 38,555). Biopsy specimens of Hodgkin's lymphomas occurring during follow-up in this combined cohort were tested serologically for the presence of EBV. Using this information, we modeled the relative risk of EBV-negative and EBV-positive Hodgkin's lymphoma in different periods after the diagnosis of infectious mononucleosis and estimated the median incubation time for mononucleosis-related EBV-positive Hodgkin's lymphoma.Only serologically confirmed infectious mononucleosis was associated with a persistently increased risk of Hodgkin's lymphoma. Sixteen of 29 tumors (55 percent), obtained from patients with infectious mononucleosis, had evidence of EBV. There was no evidence of an increased risk of EBV-negative Hodgkin's lymphoma after infectious mononucleosis. In contrast, the risk of EBV-positive Hodgkin's lymphoma was significantly increased (relative risk, 4.0; 95 percent confidence interval, 3.4 to 4.5). The estimated median incubation time from mononucleosis to EBV-positive Hodgkin's lymphoma was 4.1 years (95 percent confidence interval, 1.8 to 8.3).A causal association between infectious mononucleosis-related EBV infection and the EBV-positive subgroup of Hodgkin's lymphomas is likely in young adults. |
| Databáze: | OpenAIRE |
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