White Cell Involvement in the Inflammatory, Wound Healing, and Immune Actions of Vitamin A
| Autor: | A. Barbul, Levenson Sm, Eli Seifter, Giuseppe Rettura, Benjamin Thysen |
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| Rok vydání: | 1978 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Lymphocyte Medicine (miscellaneous) Thymus Gland Neutropenia Fractures Bone chemistry.chemical_compound Immune system Monocytosis Stress Physiological Internal medicine Adrenal Glands Leukocytes medicine Animals Leukocytosis Vitamin A Wound Healing Thymic involution Nutrition and Dietetics business.industry medicine.disease Rats Endocrinology medicine.anatomical_structure chemistry Immunology Wounds and Injuries medicine.symptom business Wound healing |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 2:129-138 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/014860717800200208 |
| Popis: | Stress or injury-induced phenomena, such as impaired wound healing and immune depression, may be related to impaired function of certain leukocyte populations. Since vitamin A prevents some aspects of stress, we studied its effect on various white cell populations in normal and injured rats. Supplemental vitamin A (150,000 IU/kg chow) to normal rats resulted in marked increases in thymic weight and lymphocytes without any effct on adrenal weight. The basal chow contains 13,700 IU vitamin A per kg. In rats subjected to moderately severe injury (dorsal wounding or unilateral femoral fracture), supplemental vitamin A greatly diminished the thymic involution observed in chow-fed controls and delayed or minimized the accompanying adrenal hypertrophy. In uninjured rats, supplemental vitamin A induced in three to four days a temporary circulatory leukocytosis characterized by lymhocytosis, monocytosis, and a relative neutropenia. These changes in the blood picture persisted one day after femoral fracture. On the second and third day postfracture the lymphocyte and neutrophil values returned to normal while the monocytosis persisted. Polyvinyl alcohol sponges implanted next to the fracture site demonstrated that supplemental vitamin A consistently increased the number of white blood cells migrating into the wound area and showed significantly larger numbers of monocytes/macrophages. These data suggest that vitamin A influences the numbers and nature of white cells involved in immune, inflammatory, and wound healing processes. In addition to the known antiglucocorticoid activity of vitamin A, these effects may represent a direct beneficial action of dietary vitamin A supplements for stressed and injured animals. |
| Databáze: | OpenAIRE |
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