Ingenamine E and Cyclostellettamines G-K from the new Brazilian species of marine sponge Pachychalina sp
| Autor: | de Oliveira, J. H. H. L., Grube, Achim, Köck, Matthias, Berlinck, R. G. S., Macedo, M. L., Ferreira, A. G., Hajdu, E., Muricy, G. |
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| Rok vydání: | 2004 |
| Předmět: |
Staphylococcus aureus
Stereochemistry medicine.drug_class Antitubercular Agents Pharmaceutical Science Antineoplastic Agents Microbial Sensitivity Tests Pharmacognosy 010402 general chemistry Antimycobacterial medicine.disease_cause Heterocyclic Compounds 4 or More Rings 01 natural sciences Analytical Chemistry Alkaloids Drug Discovery Escherichia coli Tumor Cells Cultured medicine Animals Humans Antibacterial agent Pharmacology Molecular Structure biology 010405 organic chemistry Organic Chemistry Biological activity Mycobacterium tuberculosis biology.organism_classification Enterobacteriaceae Anti-Bacterial Agents Porifera 0104 chemical sciences 3. Good health Complementary and alternative medicine Molecular Medicine Drug Screening Assays Antitumor Antibacterial activity Brazil |
| Zdroj: | EPIC3Journal of Natural Products, 67, pp. 1685-1689 |
| Popis: | The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10-14) with the known cyclostellettamines A-F (4-9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10-14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv. |
| Databáze: | OpenAIRE |
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