Biocompatibility of particles of GORE-TEX® cruciate ligament prosthesis: an investigation both, in vitro and in vivo
| Autor: | F.C. Law, L.A. Thomson, K.H. James, Neil Rushton |
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| Rok vydání: | 1991 |
| Předmět: |
Materials science
Knee Joint Biocompatibility Surface Properties Biophysics Biocompatible Materials Bioengineering Biomaterials Cruciate ligament Mice chemistry.chemical_compound In vivo Lactate dehydrogenase Acetylglucosaminidase Synovial Fluid medicine Animals Humans Particle Size Cytotoxicity Peritoneal Cavity Polytetrafluoroethylene Cells Cultured L-Lactate Dehydrogenase Macrophages Biomaterial Patella Prostheses and Implants Fibroblasts In vitro medicine.anatomical_structure chemistry Mechanics of Materials Ligaments Articular Ceramics and Composites Female Particle size Biomedical engineering |
| Zdroj: | Biomaterials. 12:781-785 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/0142-9612(91)90030-e |
| Popis: | This research was to determine the biocompatibility of simulated wear particles from a GORE-TEX cruciate ligament prosthesis using in vitro and in vivo techniques. Exposure of normal human synovial fibroblasts and primary mouse peritoneal macrophages to the particles revealed no cytotoxicity, as determined by lactate dehydrogenase release, but beta-N-acetyl-D-glucosaminidase was released from macrophages at high concentrations, showing inflammatory potential. This was not seen when the particles were injected into mouse knees, where no adverse reactions were observed. These simulated wear particles were shown to be biocompatible using these in vitro and in vivo systems. |
| Databáze: | OpenAIRE |
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