Stage IV CD30+ anaplastic large cell lymphoma: Response to acitretin and interferon-alpha
| Autor: | Colin S Ong, Mark Hertzberg, Karen Stapleton, John S. Sullivan |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Pathology CD30 medicine.medical_treatment Administration Oral Ki-1 Antigen Alpha interferon Antineoplastic Agents Dermatology Gastroenterology Acitretin Keratolytic Agents Internal medicine Skin Ulcer medicine Humans Infusions Intravenous Anaplastic large-cell lymphoma Interferon alfa Neoplasm Staging Chemotherapy business.industry Large cell Biopsy Needle Interferon-alpha Middle Aged medicine.disease Immunohistochemistry Magnetic Resonance Imaging Treatment Outcome Arm Lymphoma Large-Cell Anaplastic Drug Therapy Combination Female Methotrexate Tomography X-Ray Computed business Follow-Up Studies medicine.drug |
| Zdroj: | Australasian Journal of Dermatology. 43:207-210 |
| ISSN: | 1440-0960 0004-8380 |
| DOI: | 10.1046/j.1440-0960.2002.00597.x |
| Popis: | Retinoids and interferon (IFN)-alpha induce differentiation, affect cell proliferation and alter various immune parameters. In combination, their effects may be additive or even synergistic in the treatment of malignancy. We present a 53-year-old woman with stage IV CD30+ anaplastic large cell lymphoma with brain, lung and skin involvement. The patient had been on methotrexate for rheumatoid arthritis. After a combination of oral acitretin 50 mg daily and IFN-alpha 3 million units subcutaneously 3 times per week, the skin lesions cleared within 2 months, lung lesions by 5 months and brain lesions by 7 months. Although we cannot exclude that methotrexate played a role in the development of this lymphoma and that its withdrawal contributed to the clearance of lesions, we propose that the patient's disease responded to the combination of acitretin and IFN-alpha. |
| Databáze: | OpenAIRE |
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