Amacrine-to-Amacrine Cell Inhibition in the Rabbit Retina
| Autor: | Frank S. Werblin, Alyosha Molnar, Hain-Ann Hsueh |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Retina
Patch-Clamp Techniques Physiology Chemistry Aminobutyrates General Neuroscience In Vitro Techniques Inner plexiform layer Amacrine cell Cell biology Electrophysiology Amacrine Cells medicine.anatomical_structure medicine Animals GABAergic Anticonvulsants Gabaergic inhibition Rabbits Patch clamp Glycine receptor Photic Stimulation |
| Zdroj: | Journal of Neurophysiology. 100:2077-2088 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.90417.2008 |
| Popis: | We studied the interactions between excitation and inhibition in morphologically identified amacrine cells in the light-adapted rabbit retinal slice under patch clamp. The majority of on amacrine cells received glycinergic off inhibition. About half of the off amacrine cells received glycinergic on inhibition. Neither class received any GABAergic inhibition. A minority of on, off, and on–off amacrine cells received both glycinergic on and GABAergic off inhibition. These interactions were found in cells with diverse morphologies having both wide and narrow processes that stratify in single or multiple layers of the inner plexiform layer (IPL). Most on–off amacrine cells received no inhibition and have monostratified processes confined to the middle of the IPL. The most common interaction between amacrine cells that we measured was “crossover inhibition,” where off inhibits on and on inhibits off. Although the morphology of amacrine cells is diverse, the interactions between excitation and inhibition appear to be relatively limited and specific. |
| Databáze: | OpenAIRE |
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