NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila
| Autor: | Kathryn A. Eaton, Eric C. Martens, Nancy N. Baxter, Jiachen Chen, Patrick D. Schloss, Bryan Schaf, Natasha Golovchenko, Lili Zhao, Jonathan S. Mitchell, Nicholas A. Pudlo, Grace Y. Chen, Sergey S. Seregin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male colitis Cell Gut flora Inflammatory bowel disease Mice 0302 clinical medicine Bacteroides Colonization Intestinal Mucosa lcsh:QH301-705.5 NLRs Mice Knockout NLRP6 biology Microbiota Interleukin-18 Limiting dysbiosis Interleukin-10 Interleukin 10 medicine.anatomical_structure 030220 oncology & carcinogenesis IL-10 Female Disease Susceptibility Akkermansia muciniphila DNA Bacterial Colon Receptors Cell Surface Article General Biochemistry Genetics and Molecular Biology Microbiology 03 medical and health sciences Verrucomicrobia medicine Animals Colitis intestine Innate immune system Hyperplasia Akkermansia Sequence Analysis DNA medicine.disease biology.organism_classification Mice Inbred C57BL 030104 developmental biology lcsh:Biology (General) inflammation Immunology pathobiont Dysbiosis |
| Zdroj: | Cell Reports, Vol 19, Iss 4, Pp 733-745 (2017) Cell Reports, Vol 19, Iss 10, p 2174 (2017) |
| ISSN: | 2211-1247 |
| Popis: | Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity or the microbiota cause disease. We previously demonstrated that the loss of the innate immune receptor NLRP6 in mice resulted in impaired production of interleukin-18 (IL-18) and increased susceptibility to epithelial-induced injury. Here, we show that NLRP6 is important for suppressing the development of spontaneous colitis in the Il10-/- mice model of IBD and that NLRP6 deficiency results in the enrichment of Akkermansia muciniphila. A. muciniphila was sufficient for promoting intestinal inflammation in both specific-pathogen-free and germ-free Il10-/- mice. Our results demonstrate that A. muciniphila can act as a pathobiont to promote colitis in a genetically susceptible host and that NLRP6 is a key regulator of its abundance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|