Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

Autor:	Diego Quaresma Ferreira, José Carlos Tavares Carvalho, Rodrigo Alves Souza Cruz, Brenda Lorena Sánchez Ortiz, Jemima C. M. M. Miranda, Gisele Custódio de Souza, Rosangela S. F. R. Sarquis, Raquel Silva Araújo, Rafael Garrett, Caio P. Fernandes, Anna E.M.F.M. Oliveira, Thamara de Oliveira Ferraz
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine medicine.drug_class Danio Pharmaceutical Science Anti-inflammatory Article 03 medical and health sciences Drug Discovery medicine Caesalpinia Zebrafish biology Traditional medicine 0402 animal and dairy science Libidibia ferrea toxicity Embryo 04 agricultural and veterinary sciences biology.organism_classification zebrafish 040201 dairy & animal science Acute toxicity 030104 developmental biology Toxicity histopathology Molecular Medicine embryos
Zdroj:	Pharmaceuticals Volume 12 Issue 4
ISSN:	1424-8247
Popis:	The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart however, it is perceived to be related to the concentrations used.
Databáze:	OpenAIRE
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