The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis
| Autor: | Jin-Yan Zhao, Qing Chen, Gai-Xia Zhu, Xiang Xue |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty MEDLINE DNA Fragmentation 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences Pregnancy medicine Humans Insemination Artificial 030304 developmental biology 0105 earth and related environmental sciences Gynecology 0303 health sciences Intrauterine insemination business.industry Pregnancy Outcome medicine.disease Spermatozoa Pregnancy rate Meta-analysis DNA fragmentation Female business |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 86 |
| ISSN: | 1873-1708 |
| Popis: | Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive outcomes. A total of 10 articles retrieved from the databases of PUBMED, MEDLINE, EMBASE and WANFANG were included in the meta-analysis. The results indicated that high sperm DNA fragmentation was significantly associated with lower pregnancy rate (RR: 0.34, 95% CI: 0.22-0.52; P 0.001) and deliveries rate of IUI(RR 0.14, 95% CI:0.04-0.56, P 0.001). In addition, there was no evidence of publication bias, as suggested by funnel plot, Begg's and Egger's tests. The present meta-analysis indicated that high sperm DNA fragmentation was associated with poor reproductive outcomes of couples undergoing IUI. |
| Databáze: | OpenAIRE |
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