Facile development, characterization, and evaluation of novel bicalutamide loaded pH-sensitive mesoporous silica nanoparticles for enhanced prostate cancer therapy
| Autor: | Sadhana J. Rajput, Seema Saroj |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Bicalutamide Pharmaceutical Science Nanoparticle Antineoplastic Agents 02 engineering and technology 030226 pharmacology & pharmacy Hemolysis Tosyl Compounds 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Cell Line Tumor Drug Discovery Nitriles medicine Humans MTT assay Anilides Pharmacology Drug Carriers integumentary system Chemistry Organic Chemistry Polyacrylic acid Prostatic Neoplasms Mesoporous silica Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology medicine.disease Silicon Dioxide Drug Liberation Cancer cell Cancer research Nanoparticles Drug Screening Assays Antitumor 0210 nano-technology medicine.drug |
| Zdroj: | Drug development and industrial pharmacy. 45(4) |
| ISSN: | 1520-5762 |
| Popis: | It is a challenge to deliver therapeutics exclusively to cancer cells, while sparing the normal cells. However, pH-sensitive delivery systems have proved to be highly efficient in fulfilling this task due to their ability to provide on-demand and selective release of drug at acidic tumor sites. As a proof of concept, here pH responsive drug delivery system based on mesoporous core shell nanoparticles (NPs) surrounded with poly acrylic acid (PAA) layers were prepared employing a facile synthesis strategy. Bicalutamide (BIC) was encased into surface functionalized MCM-41 nanoparticles via electrostatic interactions. The synthesized NPs were characterized by nitrogen adsorption and desorption isotherms, SEM-EDS, TEM, LXRD, and WXRD. In vitro release studies demonstrated that BIC-MSN-PAA NPs exhibited a higher release in the acidic media which varied inversely with the increase in pH. Further, the results of cell cytotoxicity assay were evident that BICMSNs exhibited more potent killing of both PC-3 and LNCaP cells than free BIC. PAA-MSNs also exhibited an enhanced cellular uptake and prolonged circulation time in vivo. The results are suggestive of the fact that PAA functionalized MSNs can serve as an effective pH-responsive template and hold a great potential ahead in controlled release and effective cancer treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|