Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy
| Autor: | Masafumi Inomata, Yukio Iwashita, Masayuki Ohta, Yuichi Endo, Takahide Kawasaki, Kiminori Watanabe, Hiroomi Takayama, Kazuhiro Tada |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Sleeve gastrectomy Duodenum medicine.medical_treatment Gene Expression 030230 surgery Carbohydrate metabolism Rats Sprague-Dawley 03 medical and health sciences Sodium-Glucose Transporter 1 0302 clinical medicine Jejunoileal Bypass Gastrectomy Internal medicine medicine Animals Glucose Transporter Type 1 Messenger RNA biology business.industry Glucose transporter General Medicine Glucose Tolerance Test Glucose Jejunum Endocrinology Gluconeogenesis 030220 oncology & carcinogenesis Models Animal biology.protein Immunohistochemistry Surgery GLUT1 Cotransporter business |
| Zdroj: | Surgery Today. 49:637-644 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-019-1772-x |
| Popis: | Sleeve gastrectomy with duodenojejunal bypass (SG-DJB) is expected to become a popular procedure in East Asia. The aim of this study was to evaluate the effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy (SG). Twenty-four Sprague–Dawley rats were divided into two groups: SG-DJB and SG alone. 6 weeks after surgery, body weight, feed intake, and metabolic parameters were measured, and oral glucose tolerance tests (OGTT) were performed. The mRNA expression of factors related to gluconeogenesis and glucose transport was evaluated using jejunal samples. Protein expression of factors with significantly different mRNA expression levels was evaluated using immunohistochemistry. Body weight and metabolic parameters did not significantly differ between the two groups. During the OGTT, the SG-DJB group showed an early increase in serum insulin followed by an early decrease in blood glucose compared with the SG group. Expression levels of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) mRNA and protein in the alimentary limb (AL) were greater in the SG-DJB group than in the SG group. The additional effects of duodenojejunal bypass on glucose metabolism after SG may be related to increased expression of GLUT1 and SGLT1 in the AL. |
| Databáze: | OpenAIRE |
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