Neuropeptide changes in the suprachiasmatic nucleus are associated with the development of hypertension
| Autor: | Ajda Yilmaz, Ruud M. Buijs, Frederik N Buijs, Andries Kalsbeek |
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| Přispěvatelé: | Endocrinology, Laboratory for Endocrinology, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Netherlands Institute for Neuroscience (NIN) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Postmortem studies Aging endocrine system Physiology Vasoactive intestinal peptide Neuropeptide 030209 endocrinology & metabolism Blood Pressure Rats Inbred WKY 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Rats Inbred SHR medicine Animals Circadian rhythm Rats Wistar Suprachiasmatic nucleus business.industry Neuropeptides Circadian Rhythm Rats Endocrinology Blood pressure Somatostatin nervous system Hypertension Suprachiasmatic Nucleus sense organs business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Chronobiology international, 36(8), 1072-1087. Marcel Dekker Inc. Chronobiology International, 36, 1072-1087. Taylor & Francis Group |
| ISSN: | 0742-0528 |
| Popis: | Human postmortem studies as well as experimental animal studies indicate profound changes in neuropeptide expression in the suprachiasmatic nucleus (SCN) in several pathological conditions including hypertension. In addition, animal experimental observations show that the SCN peptides, vasopressin (AVP) and vasoactive intestinal peptide (VIP) are essential for adequate rhythmicity. These data prompted us to investigate whether changes in these neuronal populations could be the cause or consequence of hypertension. Changes in blood pressure and levels of neuropeptide expression in the SCN were determined during development of hypertension in spontaneously hypertensive rats (SHR), in 2K1C reno-vascular induced hypertensive animals and their respective controls. During the pre-hypertensive stage (5 weeks of age), the VIP and AVP content was higher and the somatostatin (SOM) content was lower in the SHR SCN. At the onset of hypertension (12 weeks of age), when blood pressure levels had just reached about 140 mmHg, AVP and SOM content in the SCN was not different anymore in SHRs compared to control, but VIP was still higher. After 16 weeks, the AVP content was decreased, but SOM was increased and the overall level of VIP in the SCN was still higher in SHRs compared to controls. None of the aforementioned changes in the SCN was observed after induction of hypertension in the 2K1C model. However, while VIP was increased in the NTS projecting medial region of the SCN in SHR animals only after the establishment of hypertension, VIP was decreased in the same region in the 2K1C induced hypertensive rats. Consequently, the present findings confirm previous studies in human and rat indicating that changes in the SCN are strongly associated with the development of hypertension. In addition, the changes in peptide content in the 2K1C animals indicate that the SCN is also able to respond to increases in blood pressure. |
| Databáze: | OpenAIRE |
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