Fas −670A/G (rs1800682) Polymorphism and Digestive Cancer Risk in Asians: A Meta-Analysis
| Autor: | Gai-Qin Li, Qing-Dong Liu, Yan-Qun Cong, Hai-Peng Yuan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
China
Molecular Epidemiology Regulator General Medicine Biology Fas receptor medicine.disease_cause Bioinformatics Polymorphism Single Nucleotide Apoptosis Meta-analysis Mutation Biomarkers Tumor medicine Humans SNP fas Receptor Carcinogenesis Digestive cancer Gene Genetics (clinical) Gastrointestinal Neoplasms |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 18:482-488 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2014.0032 |
| Popis: | Tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the Fas receptor-ligand system is a key regulator of apoptosis. The Fas -670 A/G single-nucleotide polymorphism (SNP) has been demonstrated to affect the expression of the Fas gene by altering the transcriptional activity in this gene's promoter. However, the association between the Fas -670 A/G polymorphism and digestive cancer risk is still controversial and ambiguous in the Asian population, so we conducted a meta-analysis to confirm and clarify the association between the Fas -670 A/G polymorphism and digestive cancer.A search of PubMed, China National Knowledge Infrastructure (CNKI), and WanFang databases was conducted and encompassed all available articles that had been published up to July 20, 2013. Overall, 15 case-control studies containing 3692 cases and 4895 controls were retrieved based on search criteria for digestive cancer susceptibility related to -670A/G SNP. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association.In the overall analysis, the country type and source of control subgroups, no association between the Fas -670 A/G polymorphism and digestive cancer risk was found. However, in the digestive cancer-type subgroups, a significant protective effect was detected between Fas -670 A/G polymorphism and hepatocellular carcinoma in Asians (AG vs. GG: OR=0.89, 95% CI=0.80-0.99; AA+AG vs. GG: OR=0.93, 95% CI=0.87-1.00).Our investigations demonstrated that the Fas -670 A/G polymorphism might decrease the hepatocellular carcinoma risk in Asian populations. Further studies based on larger sample sizes, other ethnicities, and gene-environment interactions should be conducted to further understand the role of Fas -670 A/G polymorphism in digestive cancer risk. |
| Databáze: | OpenAIRE |
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