6-Hydroxydopamine-induced degeneration of nigral dopamine neurons: differential effect on nigral and striatal D-1 dopamine receptors
| Autor: | G. De Montis, S. Mele, Giovanni Biggio, Maria Luisa Porceddu, L. Cocco, Osvaldo Giorgi, Ennio Ongini |
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| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Nigrostriatal pathway Substantia nigra Striatum Biology General Biochemistry Genetics and Molecular Biology Receptors Dopamine chemistry.chemical_compound Internal medicine medicine Animals heterocyclic compounds Neurons Afferent General Pharmacology Toxicology and Pharmaceutics Neurons Receptors Dopamine D1 Dopaminergic Rats Inbred Strains General Medicine Benzazepines Corpus Striatum Rats Substantia Nigra medicine.anatomical_structure Endocrinology nervous system chemistry Dopamine receptor Nerve Degeneration Cyclase activity Oxidopamine medicine.drug Adenylyl Cyclases |
| Zdroj: | Life sciences. 41(6) |
| ISSN: | 0024-3205 |
| Popis: | Dopamine-sensitive adenylate cyclase and 3H-SCH 23390 binding parameters were measured in the rat substantia nigra and striatum 15 days after the injection of 6-hydroxydopamine into the medial forebrain bundle. The activity of nigral dopamine-sensitive adenylate cyclase and the binding of 3H-SCH 23390 to rat nigral D-1 dopamine receptors were markedly decreased after the lesion. On the contrary, 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway enhanced both adenylate cyclase activity and the density of 3H-SCH 23390 binding sites in striatal membrane preparations. The changes in 3H-SCH 23390 binding found in both nigral and striatal membrane preparations were associated with changes in the total number of binding sites with no modifications in their apparent affinity. The results indicate that: within the substantia nigra a fraction (30%) of D-1 dopamine receptors coupled to the adenylate cyclase is located on cell bodies and/or dendrites of dopaminergic neurons; striatal D-1 dopamine receptors are tonically innervated by nigrostriatal afferent fibers. |
| Databáze: | OpenAIRE |
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