Distinguishing Depressive Pseudodementia from Alzheimer Disease: A Comparative Study of Hippocampal Volumetry and Cognitive Tests
| Autor: | Tugba Okluoglu Önal, Sevki Sahin, Nilgun Cinar, Rahmi Cubuk, Sibel Karsidag, Meral Bozdemir |
|---|---|
| Přispěvatelé: | Maltepe Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
Wechsler Memory Scale
medicine.medical_specialty Cognitive Neuroscience lcsh:Geriatrics Audiology behavioral disciplines and activities lcsh:RC346-429 03 medical and health sciences Cognition Magnetic resonance imaging 0302 clinical medicine medicine Dementia Original Research Article Psychiatry lcsh:Neurology. Diseases of the nervous system Depression Pseudodementia medicine.disease 030227 psychiatry Cognitive test lcsh:RC952-954.6 Psychiatry and Mental health Boston Naming Test Geriatric Depression Scale Alzheimer disease Alzheimer's disease Psychology 030217 neurology & neurosurgery Stroop effect |
| Zdroj: | Dementia and Geriatric Cognitive Disorders EXTRA Dementia and Geriatric Cognitive Disorders Extra, Vol 7, Iss 2, Pp 230-239 (2017) |
| ISSN: | 1664-5464 |
| DOI: | 10.1159/000477759 |
| Popis: | WOS: 000410960800005 PubMed ID: 28868066 Background and Aim: Depressive pseudodementia (DPD) is a condition which may develop secondary to depression. The aim of this study was to contribute to the differential diagnosis between Alzheimer disease (AD) and DPD by comparing the neurocognitive tests and hippocampal volume. Materials and Methods: Patients who met criteria of AD/DPD were enrolled in the study. All patients were assessed using the Wechsler Memory Scale (WMS), clock-drawing test, Stroop test, Benton Facial Recognition Test (BFRT), Boston Naming Test, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS). Hippocampal volume was measured by importing the coronal T1-weighted magnetic resonance images to the Vitrea 2 workstation. Results: A significant difference was found between the AD and DPD groups on the WMS test, clock-drawing test, Stroop test, Boston Naming Test, MMSE, GDS, and left hippocampal volume. A significant correlation between BFRT and bilateral hippocampal volumes was found in the AD group. No correlation was found among parameters in DPD patients. Conclusions: Our results suggest that evaluation of facial recognition and left hippocampal volume may provide more reliable evidence for distinguishing DPD from AD. Further investigations combined with functional imaging techniques including more patients are needed. (C) 2017 The Author(s) Published by S. Karger AG, Basel |
| Databáze: | OpenAIRE |
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