Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study
| Autor: | Lindsey Buckingham, Divya K. Shah, Jenna Lipson Kahn, Mary D. Sammel, Nathanael Koelper |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Infertility
medicine.medical_specialty Reproductive endocrinology and infertility Population lcsh:RC870-923 lcsh:Gynecology and obstetrics Endometrial cancer Medicine risk factors Risk factor education lcsh:RG1-991 education.field_of_study business.industry Obstetrics Incidence (epidemiology) Case-control study Odds ratio medicine.disease lcsh:Diseases of the genitourinary system. Urology atypical hyperplasia incidence Original Article business infertility |
| Zdroj: | F&S Reports, Vol 2, Iss 1, Pp 104-108 (2021) F&S Reports |
| ISSN: | 2666-3341 |
| Popis: | Objective To estimate the incidence and identify risk factors for atypical endometrial hyperplasia (AH) and endometrial cancer (EC) in American women undergoing infertility evaluation. Design Case-control study. Setting Academic reproductive endocrinology and infertility practice. Patient(s) Female patients (18–50 years) seeking infertility evaluation from January 1, 2009 to December 1, 2018. Patients with known genetic predisposition to cancer or prior cancer diagnosis were excluded. Cases were defined as patients diagnosed with AH or EC during infertility workup (n = 22). Controls without AH or EC were randomly selected in a 10:1 ratio (n = 220) from all women undergoing infertility evaluation in the same year. Intervention(s) None. Main Outcome Measure(s) Incidence of AH or EC and odds of AH or EC accounting for age, race, body mass index (BMI), and ovulatory dysfunction. Result(s) Twenty-two cases of AH or EC were identified among 11,569 women undergoing infertility evaluation (incidence 2 per 1,000 women, 95% confidence interval [CI] 1.2–2.9 per 1,000). Of these women, 68% had a BMI ≥30 kg/m2 compared with 25% of controls. In multivariable analyses, women with a BMI ≥30 kg/m2 were 5.9 times more likely to be diagnosed with AH or EC (adjusted odds ratio 5.9, 95% CI 2.0–17.2). Women with ovulatory dysfunction were 3.4 times more likely to be diagnosed with AH or EC (adjusted odds ratio 3.4, 95% CI 1.1–10.1). Conclusion(s) The incidence of AH and EC in a population of women undergoing infertility evaluation is 10 times that in the general population of premenopausal women. Obesity is the strongest independent risk factor for AH and EC in women with infertility. |
| Databáze: | OpenAIRE |
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