Microbial contributions to chronic inflammation and metabolic disease
| Autor: | Donal Sheehan, Fergus Shanahan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Inflammation Dietary factors Gut flora Bioinformatics 03 medical and health sciences 0302 clinical medicine Immune system Metabolic Diseases Animals Humans Medicine Precision Medicine Metabolic disease Nutrition and Dietetics biology business.industry Precision medicine biology.organism_classification Anti-Bacterial Agents Diet Gastrointestinal Microbiome 030104 developmental biology Immune System Diseases Environmental Risk Factor Dysbiosis medicine.symptom business Metabolic activity 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Clinical Nutrition & Metabolic Care. 19:257-262 |
| ISSN: | 1363-1950 |
| Popis: | Purpose of review It is long known that immune and metabolic cascades intersect at various cross-points. More recently, the regulatory influence of the microbiota on both of these cascades has emerged. Advances with therapeutic implications for chronic immunologic and metabolic disorders are examined. Recent findings Disturbances of the microbiota, particularly in early life, may be the proximate environmental risk factor in socioeconomically developed societies for development of chronic immune-allergic and metabolic disorders, including obesity. Antibiotics and dietary factors contribute to this risk. Multiple microbial signalling molecules mediate host-microbe interactions including bacterial metabolites such as short-chain fatty acids, bile salts and others. Summary New strategies for manipulating the composition and metabolic activity of the gut microbiota have emerged and offer a realistic prospect of personalized therapeutic options in immune and metabolic diseases. |
| Databáze: | OpenAIRE |
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