Near Complete Response in a Patient with Classical Hodgkin Lymphoma Treated with Brentuximab Vedotin Concurrent with Radiation Therapy
| Autor: | Tristan Smith, Dennis Andrew Buck, Wilbur Nelson Montana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Antibody-drug conjugate medicine.medical_treatment Dacarbazine Classical Hodgkin lymphoma Case Report Bleomycin lcsh:RC254-282 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Brentuximab Internal medicine hemic and lymphatic diseases medicine Brentuximab vedotin Chemotherapy business.industry Concurrent radiation lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Vinblastine 030104 developmental biology chemistry Monomethyl auristatin E ABVD 030220 oncology & carcinogenesis business medicine.drug |
| Zdroj: | Case Reports in Oncology Case Reports in Oncology, Vol 10, Iss 3, Pp 795-801 (2017) |
| ISSN: | 1662-6575 |
| Popis: | Brentuximab vedotin, an antibody drug conjugate that delivers monomethyl auristatin E into CD-30 expressing cells is FDA approved for the treatment of patients with Hodgkin lymphoma after the failure of autologous stem cell transplantation or at least 2 prior multi-agent chemotherapy regiments. This approval was based on a study that showed an overall response rate of 75% and complete remission in 34%. We present a case of a 24-year-old male with classical nodular sclerosing Hodgkin lymphoma who achieved near complete remission following 5 cycles of brentuximab concurrent with ISRT (involved site radiation therapy) following progression of first-line ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) and subsequent second-line ICE (ifosfamide, carboplatin, etoposide) chemotherapy. This case not only reiterates the efficacy of brentuximab vedotin in the third-line setting but introduces the role of and need for further clinical trials of combined radiotherapy with brentuximab in Hodgkin lymphoma patients following failure of second-line options. |
| Databáze: | OpenAIRE |
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