Order of Inoculation during Heligmosomoides bakeri and Hymenolepis microstoma Coinfection Alters Parasite Life History and Host Responses
| Autor: | Alaa Saghbini, W. Ward, Deborah M. Kristan, Samantha Lang, Paul Clark |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
life history Hymenolepis microstoma Zoology lcsh:Medicine host plasticity coinfection Nematode Heligmosomoides bakeri Cestode Article medicine Immunology and Allergy Parasite hosting Molecular Biology Larva General Immunology and Microbiology biology Host (biology) lcsh:R biology.organism_classification medicine.disease Infectious Diseases Alanine transaminase Immunology Coinfection biology.protein Microstoma |
| Zdroj: | Pathogens, Vol 2, Iss 1, Pp 130-152 (2013) Pathogens Pathogens; Volume 2; Issue 1; Pages: 130-152 |
| ISSN: | 2076-0817 |
| Popis: | Parasite life history may differ during coinfection compared to single infections, and the order of infection may be an important predictor of life history traits. We subjected laboratory mice (Mus musculus) to single and coinfections with Heligmosomoides bakeri and Hymenolepis microstoma and measured life history traits of worms and also hepatobiliary and morphological responses by the host. We found that fewer H. bakeri larvae established, and adult worms were shorter and produced fewer eggs during a coinfection where H. microstoma occurred first. H. microstoma grew more and released more eggs after simultaneous inoculation of both parasites compared to a single H. microstoma infection, despite similar worm numbers. Mouse small intestine mass, but not length, varied with coinfection and bile duct mass was largest when H. microstoma was given alone or first. Mouse serum alkaline phosphatase levels were greatest for mice infected with H. microstoma only but did not vary with number of scolices; no change in mouse serum alanine transaminase levels was observed. Overall, the order of coinfection influenced life history traits of both H. bakeri and H. microstoma, but changes in survival, growth, and reproduction with order of inoculation were not consistent between the two parasites. |
| Databáze: | OpenAIRE |
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