Diagnosis of Levothyroxine Pseudo-malabsorption: The Results of Standardised Testing Protocol
Autor: | Alev Selek, Mehmet Sözen, Berrin Çetinarslan, Zeynep Cantürk, Ilhan Tarkun, Emre Gezer |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Malabsorption business.industry Low dose Levothyroxine Thyrotropin General Medicine Thyroid Function Tests medicine.disease Gastroenterology Observational Studies as Topic Thyroxine Hypothyroidism Basal (medicine) Thyroid-stimulating hormone Refractory Internal medicine medicine Humans Peak level Differential diagnosis business hormones hormone substitutes and hormone antagonists Retrospective Studies medicine.drug |
Zdroj: | Journal of the College of Physicians and Surgeons Pakistan. 31:1099-1101 |
ISSN: | 1681-7168 1022-386X |
Popis: | The levothyroxine absorption test for the assessment of pseudo-malabsorption in patients with refractory hypothyroidism has not been standardised. The aim of this observational study was to describe a protocol for levothyroxine (LT-4) absorption test in patients with refractory hypothyroidism, to report possible side effects and to emphasise the importance of pseudo-malabsorption in the differential diagnosis. The results of 10 patients, who underwent LT-4 absorption tests because thyroid stimulating hormone suppression could not be achieved despite the need for LT-4 >3 mcg/kg/day, were retrospectively analysed. When compared with basal free T4 (fT4), a statistically significant increase in fT4 was observed after the first hour (p=0.012). fT4 reached its peak level and plateau at the 4th hour. The fT4 peak level increased 3.25 times compared to baseline. The shorter LT-4 absorption test with low doses may provide an alternative method to the commonly used longer protocols with higher doses to rule out malabsorption. Key Words: Levothyroxine absorption test, Pseudo-malabsorption, Resistant hypothyroidism. |
Databáze: | OpenAIRE |
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