Targeting ubiquilin-1 in Alzheimer's disease
Autor: | Mari Takalo, Hilkka Soininen, Rudolph E. Tanzi, Teemu Natunen, Mikko Hiltunen, Annakaisa Haapasalo, Jayashree Viswanathan, Kaisa M.A. Kurkinen |
---|---|
Rok vydání: | 2013 |
Předmět: |
Pharmacology
education.field_of_study biology Clinical Biochemistry Population Autophagy-Related Proteins Cell Cycle Proteins Context (language use) Disease Virology Presenilin Biochemistry of Alzheimer's disease Aggresome Alzheimer Disease Drug Discovery biology.protein Amyloid precursor protein Animals Humans Molecular Medicine Carrier Proteins education Amyloid precursor protein secretase Neuroscience Adaptor Proteins Signal Transducing |
Zdroj: | Expert Opinion on Therapeutic Targets. 17:795-810 |
ISSN: | 1744-7631 1472-8222 |
Popis: | Alzheimer's disease (AD) is a common neurodegenerative disorder affecting an increasing number of people worldwide as the population ages. Currently, there are no drugs available that could prevent AD pathogenesis or slow down its progression. Increasing evidence links ubiquilin-1, an ubiquitin-like protein, into the pathogenic mechanisms of AD and other neurodegenerative diseases. Ubiquilin-1 has been shown to play a key role in the regulation of the levels, subcellular targeting, aggregation and degradation of various neurodegenerative disease-associated proteins. These include the amyloid precursor protein and presenilins that are intimately involved in the mechanisms of AD.Here, the properties and diverse functions of ubiquilin-1 protein in the context of the pathogenesis of AD and other neurodegenerative disorders are discussed. This review recapitulates the available knowledge on the involvement of ubiquilin-1 in the genetic and molecular mechanisms in AD. Furthermore, the association of ubiquilin-1 with specific proteins and mechanisms involved in the pathogenesis of neurodegenerative diseases is described and the known ubiquilin-1-interacting proteins summarized.The variety of ubiquilin-1-interacting proteins and its central role in the regulation of protein levels and degradation provides a number of novel candidates and approaches for future research and drug discovery. |
Databáze: | OpenAIRE |
Externí odkaz: |