Association of age and disease duration with comorbidities and disability: A study of the Swiss Multiple Sclerosis Registry

Autor: Mina Stanikić, Anke Salmen, Andrew Chan, Jens Kuhle, Marco Kaufmann, Sabin Ammann, Sandra Schafroth, Stephanie Rodgers, Christina Haag, Caroline Pot, Christian P Kamm, Chiara Zecca, Claudio Gobbi, Pasquale Calabrese, Zina-Mary Manjaly, Viktor von Wyl
Přispěvatelé: University of Zurich, von Wyl, Viktor
Rok vydání: 2022
Předmět:
Zdroj: Multiple Sclerosis and Related Disorders, 67
Stanikić, Mina; Salmen, Anke; Chan, Andrew; Kuhle, Jens; Kaufmann, Marco; Ammann, Sabin; Schafroth, Sandra; Rodgers, Stephanie; Haag, Christina; Pot, Caroline; Kamm, Christian P; Zecca, Chiara; Gobbi, Claudio; Calabrese, Pasquale; Manjaly, Zina-Mary; von Wyl, Viktor (2022). Association of age and disease duration with comorbidities and disability: A study of the Swiss Multiple Sclerosis Registry. Multiple Sclerosis and Related Disorders, 67, p. 104084. Elsevier 10.1016/j.msard.2022.104084
ISSN: 2211-0356
2211-0348
DOI: 10.48350/171828
Popis: Background While comorbidities increase with age, duration of multiple sclerosis (MS) leads to disability accumulation in persons with MS. The influence of ageing vis-a-vis MS duration remains largely unexplored. We studied the independent associations of ageing and MS duration with disability and comorbidities in the Swiss MS Registry participants. Methods Self-reported data was cross-sectionally analyzed using confounder-adjusted logistic regression models for 6 outcomes: cancer, type 2 diabetes (T2D), hypertension, cardiac diseases, depression, and having at least moderate or severe gait disability. Using cubic splines, we explored non-linear changes in risk shapes. Results Among 1615 participants age was associated with cardiac diseases (OR 1.05, 95% CI [1.02, 2.08]), hypertension (OR 1.08, 95% CI [1.06, 2.10]), T2D (OR 1.10, 95%CI [1.05, 1.16]) and cancer (OR 1.04, 95% CI [1.01, 1.07]). MS duration was not associated with comorbidities, except for cardiac diseases (OR 1.03, 95% CI [1.00, 1.06]). MS duration and age were independently associated with having at least moderate gait disability (OR 1.06, 95% CI [1.04, 1.07]; OR 1.04, 95% CI [1.02, 1.05], respectively), and MS duration was associated with severe gait disability (OR 1.05, 95% CI [1.03, 1.08]). The spline analysis suggested a non-linear increase of having at least moderate gait disability with age. Conclusions Presence of comorbidities was largely associated with age only. Having at least moderate gait disability was associated with both age and MS duration, while having severe gait disabity was associated with MS duration only.
Multiple Sclerosis and Related Disorders, 67
ISSN:2211-0356
ISSN:2211-0348
Databáze: OpenAIRE
Externí odkaz: