Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data
| Autor: | M. J. Oostindiër, W. M. Kloosterman-Boele, Hans F. A. Vasen, D. A. van Dijk, Pieta Krijnen |
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| Jazyk: | angličtina |
| Předmět: |
Male
Cancer Research Quality Assurance Health Care Colorectal cancer Epidemiology Medicine Genetics(clinical) Registries Family history Medical History Taking Genetics (clinical) Netherlands medicine.diagnostic_test Middle Aged Lynch syndrome Pedigree Oncology Practice Guidelines as Topic Female Guideline Adherence Colorectal Neoplasms medicine.medical_specialty Amsterdam criteria Hereditary non-polyposis colorectal cancer congenital hereditary and neonatal diseases and abnormalities Bethesda criteria Documentation Internal medicine Genetics Humans Genetic Predisposition to Disease Genetic Testing Genetic testing Aged Gynecology Family Health Original Paper business.industry Cancer nutritional and metabolic diseases medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Cancer registry Mutation Microsatellite instability business Microsatellite Repeats |
| Zdroj: | Familial Cancer |
| ISSN: | 1389-9600 |
| DOI: | 10.1007/s10689-006-9114-8 |
| Popis: | In the diagnostic work-up of hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome), high-risk patients can be identified using information from the family history on cancer (‘Amsterdam criteria’ and ‘Bethesda guidelines’). To investigate to what extent the medical specialists apply these criteria to patients with colorectal carcinoma and a suspicion of HNPCC, we collected information on diagnostic work-up of 224 patients of seven hospitals in the region of the Comprehensive Cancer Centre West in Leiden, The Netherlands. These patients were diagnosed with colorectal cancer between 1999 and 2001 and satisfied at least one of the Bethesda guidelines. A complete family history was recorded for 38 of the 244 patients (16%). Patients with a complete family history were more likely to be referred to the Clinical Genetic Centre than those with an incomplete or absent family history (53% vs. 13% and 4%, respectively; P |
| Databáze: | OpenAIRE |
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