Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation
| Autor: | Tomi Rantamäki, Samuel Kohtala, Outi Salminen, Sakari Leino, Saara Rannanpää, Sini K. Koski |
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| Přispěvatelé: | Regenerative pharmacology group, Division of Pharmacology and Pharmacotherapy, Clinical Pharmacy Group, Faculty of Pharmacy, Laboratory of Neurotherapeutics, Biosciences, Drug Research Program, Physiology and Neuroscience (-2020), Outi Salminen / Principal Investigator, Divisions of Faculty of Pharmacy, DAPHNE - Developing Assessment Practices in Higher Education, Teachers' Academy |
| Rok vydání: | 2018 |
| Předmět: |
Alpha7 nicotinic receptors
0301 basic medicine Dyskinesia Drug-Induced Quinuclidines alpha7 Nicotinic Acetylcholine Receptor INCREASES Dopamine Parkinson's disease Dopamine Agents Levodopa Nicotine Random Allocation chemistry.chemical_compound 0302 clinical medicine PARKINSONS-DISEASE SYNAPTIC PLASTICITY Medicine Nicotinic Agonists General Neuroscience lcsh:QP351-495 Brain 3. Good health Nicotinic acetylcholine receptor Nicotinic agonist Female MOTOR Research Article medicine.drug EXPRESSION medicine.medical_specialty IMPROVEMENT Partial agonist lcsh:RC321-571 RATS 03 medical and health sciences Cellular and Molecular Neuroscience Parkinsonian Disorders Internal medicine Animals Furans lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Brain-derived neurotrophic factor Levodopa-induced dyskinesia business.industry Brain-Derived Neurotrophic Factor 3112 Neurosciences AZD0328 AQW051 eye diseases Mice Inbred C57BL MODEL lcsh:Neurophysiology and neuropsychology BDNF 030104 developmental biology Endocrinology nervous system chemistry Parkinson’s disease business 030217 neurology & neurosurgery DOPA-INDUCED DYSKINESIAS |
| Zdroj: | BMC Neuroscience BMC Neuroscience, Vol 19, Iss 1, Pp 1-10 (2018) |
| ISSN: | 1471-2202 |
| DOI: | 10.1186/s12868-018-0478-0 |
| Popis: | Background The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic denervation. While the mechanisms of LID remain incompletely understood, elevated corticostriatal levels of the brain-derived neurotrophic factor (BDNF) have been suggested to play a role. Here, female mice with near-total unilateral 6-hydroxydopamine-induced nigrostriatal lesions were chronically treated with levodopa, and the effects of the α7 nicotinic receptor partial agonist AZD0328 and nicotine on LID were assessed. At the end of the experiment, BDNF protein levels in the prefrontal cortex and striatum were measured. Results Five-day treatments with three escalating doses of AZD0328 and a 10-week treatment with nicotine failed to alleviate LID. BDNF levels in the lesioned striatum correlated positively with LID severity, but no evidence was found for a levodopa-induced elevation of corticostriatal BDNF in the lesioned hemisphere. The nicotine treatment decreased BDNF levels in the prefrontal cortex but had no effect on striatal BDNF. Conclusions The findings suggest that treatment of LID with nicotinic agonists may lose its effectiveness as the disease progresses, represent further evidence for a role for BDNF in LID, and expand previous knowledge on the effects of long-term nicotine treatment on BDNF. Electronic supplementary material The online version of this article (10.1186/s12868-018-0478-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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