Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice
| Autor: | Kyle J. Wolf, Ehsan Khafipour, Joseph G. Daft, Riley Hartmann, Robin G. Lorenz, Scott M. Tanner |
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| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
DNA Bacterial medicine.medical_specialty Histology Firmicutes type 1 diabetes mouse model Drinking 030209 endocrinology & metabolism Fresh Water Nod Microbiology Diabetes Mellitus Experimental 03 medical and health sciences Feces Mice 0302 clinical medicine Mice Inbred NOD Internal medicine Diabetes mellitus Lactobacillus medicine microbiota Animals Bacteroides 030304 developmental biology NOD mice 2. Zero hunger Clostridium 0303 health sciences Type 1 diabetes biology T-cells Interleukin-17 FOXP3 Forkhead Transcription Factors Articles Hydrogen-Ion Concentration medicine.disease biology.organism_classification 3. Good health Gastrointestinal Tract Endocrinology Diabetes Mellitus Type 1 Female Interleukin 17 Anatomy diet |
| Zdroj: | Journal of Histochemistry and Cytochemistry |
| ISSN: | 1551-5044 |
| Popis: | Infant formula and breastfeeding are environmental factors that influence the incidence of Type 1 Diabetes (T1D) as well as the acidity of newborn diets. To determine if altering the intestinal microbiome is one mechanism through which an acidic liquid plays a role in T1D, we placed non-obese diabetic (NOD)/ShiLtJt mice on neutral (N) or acidified H2O and monitored the impact on microbial composition and diabetes incidence. NOD-N mice showed an increased development of diabetes, while exhibiting a decrease in Firmicutes and an increase in Bacteroidetes, Actinobacteria, and Proteobacteria from as early as 2 weeks of age. NOD-N mice had a decrease in the levels of Foxp3 expression in CD4+Foxp3+ cells, as well as decreased CD4+IL17+ cells, and a lower ratio of IL17/IFNγ CD4+ T-cells. Our data clearly indicates that a change in the acidity of liquids consumed dramatically alters the intestinal microbiome, the presence of protective Th17 and Treg cells, and the incidence of diabetes. This data suggests that early dietary manipulation of intestinal microbiota may be a novel mechanism to delay T1D onset in genetically pre-disposed individuals. |
| Databáze: | OpenAIRE |
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