Synthesis and biological evaluation of analogues of bacterial lipid I

Autor:	Michael J. Sofia, Arthur A. Branstrom, Eugene R. Baizman, Domingos J. Silva, Caryn Lang Bowe
Rok vydání:	2001
Předmět:	Stereochemistry Clinical Biochemistry Molecular Sequence Data Pharmaceutical Science Peptide Peptidoglycan Muramic acid N-Acetylglucosaminyltransferases Biochemistry Substrate Specificity chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Peptide synthesis Structure–activity relationship Moiety Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Polyisoprenyl Phosphate Monosaccharides Bacteria Organic Chemistry Cell Membrane Biological activity Enzyme chemistry Muramic Acids Molecular Medicine lipids (amino acids peptides and proteins) Glycolipids Bacterial Outer Membrane Proteins
Zdroj:	Bioorganicmedicinal chemistry letters. 10(24)
ISSN:	0960-894X
Popis:	Bacterial Lipid I analogues containing different anomeric groups at the muramic acid moiety were synthesized and screened in MurG enzyme assays run in the presence and absence of cell wall membranes. The results obtained in this study help elucidate the role of the lipid diphosphate in the recognition of Lipid I by MurG.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654e58933d27b53430dd03ff5d98f5d https://pubmed.ncbi.nlm.nih.gov/11133098 Zobrazit plný text záznamu Full Text from ScienceDirect