Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems
| Autor: | Jia-Zhi Liao, Jingjun Yan, Xing-Xing He, Ju-Sheng Lin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Carcinoma
Hepatocellular Antineoplastic Agents Transferrin receptor Asialoglycoprotein Receptor Pharmacology medicine Animals Humans Doxorubicin Molecular Targeted Therapy Epidermal growth factor receptor Drug Carriers biology business.industry Liver Neoplasms CD44 Gene Transfer Techniques General Medicine medicine.disease ErbB Receptors Folate receptor Hepatocellular carcinoma Cancer research biology.protein Nanoparticles RNA Interference Asialoglycoprotein receptor Liver cancer business medicine.drug |
| Zdroj: | Tumor Biology. 36:55-67 |
| ISSN: | 1423-0380 1010-4283 |
| Popis: | Patients with hepatocellular carcinoma (HCC) usually present at advanced stages and do not benefit from surgical resection, so drug therapy should deserve a prominent place in unresectable HCC treatment. But chemotherapy agents, such as doxorubicin, cisplatin, and paclitaxel, frequently encounter important problems such as low specificity and non-selective biodistribution. Recently, the development of nanotechnology led to significant breakthroughs to overcome these problems. Decorating the surfaces of nanoparticulate-based drug carriers with homing devices has demonstrated its potential in concentrating chemotherapy agents specifically to HCC cells. In this paper, we reviewed the current status of active targeting strategies for nanoparticulate systems based on various receptors such as asialoglycoprotein receptor, transferrin receptor, epidermal growth factor receptor, folate receptor, integrin, and CD44, which are abundantly expressed on the surfaces of hepatocytes or liver cancer cells. Furthermore, we pointed out their merits and defects and provided theoretical references for further research. |
| Databáze: | OpenAIRE |
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