Mesalamine Protects Against Colorectal Cancer in Inflammatory Bowel Disease
| Autor: | Chetan Pai, Ann L. Silverman, Omar Sharif, Jeffrey Tang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Colorectal cancer Population Risk Assessment Inflammatory bowel disease Gastroenterology Aminosalicylate Young Adult chemistry.chemical_compound Folic Acid Gastrointestinal Agents Mesalazine Risk Factors Internal medicine Odds Ratio medicine Anticarcinogenic Agents Humans Mesalamine education Retrospective Studies education.field_of_study Crohn's disease Chi-Square Distribution business.industry Anti-Inflammatory Agents Non-Steroidal Case-control study Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases Logistic Models Treatment Outcome ROC Curve chemistry Case-Control Studies Disease Progression Female Colorectal Neoplasms business |
| Zdroj: | Digestive Diseases and Sciences. 55:1696-1703 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-009-0942-x |
| Popis: | Individuals with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer (CRC) compared with the general population. Previous studies show this risk is strongly associated with dysplasia, extent of disease, duration of disease, and degree of inflammation, while chemoprevention of CRC has less support.Evaluate factors influencing risk of colorectal cancer development in inflammatory bowel disease patients.IBD patients with CRC were matched to controls by IBD type, age at diagnosis, sex, race, extent of disease, and disease duration. We compared body mass index, family history of IBD, family history of CRC, tobacco use, and cumulative and daily use of aminosalicylates, immunomodulators, folic acid, steroids, and nonsteroidal anti-inflammatory drugs. Statistical analysis was performed with logistic regression and receiver operating characteristic (ROC) curves.Of 1,594 IBD patients, 30 CRC patients were identified. Of these, 18 CRC patients were matched to 30 controls. More control patients used a cumulative aminosalicylate dose ofor=4,500 g (46.6% versus 5.6%; P = 0.047), folic acid (40.0% versus 16.7%; P = 0.002), cumulative folic acid dose ofor=1,400 mg (30.0% versus 11.1%; P = 0.014), and average daily folic acid dose ofor=1 mg (30.0% versus 16.7%; P = 0.002) compared with CRC patients. Multivariate analysis showed that a cumulative aminosalicylate dose ofor=4,500 g reduced the risk of CRC by 97.6% (P = 0.047). Folic acid reduced CRC risk by 89% (P = 0.002).Aminosalicylate and folic acid use may decrease the risk of CRC among IBD patients. |
| Databáze: | OpenAIRE |
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