Ductoscopic Detection of Intraductal Lesions in Cases of Pathologic Nipple Discharge in Comparison with Standard Diagnostics: The German Multicenter Study
Autor: | Marek Zygmunt, Andrea Stomps, Oumar Camara, Thomas Kohlmann, Katrin Hegenscheid, Stefan Paepke, Markus Hahn, Jens-Uwe Blohmer, Uwe Peisker, Ulrich Deichert, Wenke Hahndorf, Kirsten Utpatel, Ralf Ohlinger, Susanne Grunwald, Ines Buchholz |
---|---|
Rok vydání: | 2014 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty Ductal lavage Breast Neoplasms Nipple discharge Young Adult Breast cancer Germany Cytology medicine Humans Mammography Therapeutic Irrigation Aged Aged 80 and over Ductoscopy medicine.diagnostic_test business.industry Carcinoma Ductal Breast Endoscopy Magnetic resonance imaging Hematology Middle Aged medicine.disease Surgery Carcinoma Intraductal Noninfiltrating Oncology Nipples Female Ultrasonography Mammary Radiology medicine.symptom business Galactography |
Zdroj: | Oncology Research and Treatment. 37:628-632 |
ISSN: | 2296-5262 2296-5270 |
Popis: | SummaryBackground: According to the literature, ductoscopy is gaining increasing importance in the diagnosis of intraductal anomalies in cases of pathologic nipple discharge. In a multicenter study, the impact of this method was assessed in comparison with that of standard diagnostics. Patients and Methods: Between 09/2006 and 05/2009, a total of 214 patients from 7 German breast centers were included. All patients underwent elective ductoscopy and subsequent ductal excision because of pathologic nipple discharge. Ductoscopy was compared with the following standard diagnostics: breast sonography, mammography, magnetic resonance imaging (MRI), galactography, cytologic nipple swab, and ductal lavage cytology. The histological and imaging results were compared and contrasted to the results obtained from the nipple swab and cytologic assessment. Results: Sonography had the highest (82.9%) sensitivity, followed by MRI (82.5%), galactography (81.3%), ductoscopy (71.2%), lavage cytology (57.8%), mammography (57.1%), and nipple swab (22.8%). Nipple swabs had the highest (85.5%) specificity, followed by lavage cytology (85.2%), ductoscopy (49.4%), galactography (44.4%), mammography (33.3%), sonography (17.9%), and MRI (11.8%). Conclusion: Currently, ductoscopy provides a direct intraoperative visualization of intraductal lesions. Sensitivity and specificity are similar to those of standard diagnostics. The technique supports selective duct excision, in contrast to the unselective technique according to Urban. Therefore, ductoscopy extends the interventional/diagnostic armamentarium. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |