Recent versus chronic exposure to particulate matter air pollution in association with neurobehavioral performance in a panel study of primary schoolchildren
| Autor: | Nelly D. Saenen, Charlotte Vanpoucke, Mineke K. Viaene, Harry Roels, Tim S. Nawrot, Eline B. Provost, Wouter Lefebvre, Karen Vrijens |
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| Přispěvatelé: | UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Chronic exposure medicine.medical_specialty Air pollution exposure Air pollution 010501 environmental sciences Audiology medicine.disease_cause 01 natural sciences 03 medical and health sciences Neurobehavior Soot Interquartile range Air Pollution medicine Memory span Humans Child Children Simulation lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science particulate matter air pollution neurobehavior children repeated measures lcsh:GE1-350 Air Pollutants business.industry Repeated measures design Environmental Exposure Particulates Memory Short-Term 030104 developmental biology Noise Transportation Air Pollution Indoor Stroop Test Female Particulate Matter Repeated measures business Particulate matter Psychomotor Performance Stroop effect |
| Zdroj: | Environment International, Vol. 95, p. 112-119 (2016) Environment International, Vol 95, Iss, Pp 112-119 (2016) |
| Popis: | Children's neuropsychological abilities are in a developmental stage. Recent air pollution exposure and neurobehavioralperformance are scarcely studied. In a panel study, we repeatedly administered to each child the followingneurobehavioral tests: Stroop Test (selective attention) and Continuous Performance Test (sustainedattention), Digit Span Forward and Backward Tests (short-term memory), and Digit-Symbol and Pattern ComparisonTests (visual information processing speed). At school, recent inside classroom particulate matter ≤2.5or 10 μm exposure (PM2.5, PM10) was monitored on each examination day. At the child's residence, recent(same day up to 2 days before) and chronic (365 days before examination) exposures to PM2.5, PM10 and blackcarbon (BC) were modeled. Repeated neurobehavioral test performances (n = 894) of the children (n = 310)reflected slower Stroop Test (p = 0.05) and Digit-Symbol Test (p = 0.01) performances with increasing recentinside classroom PM2.5 exposure. An interquartile range (IQR) increment in recent residential outdoor PM2.5 exposurewas associated with an increase in average latency of 0.087 s (SE: ±0.034; p = 0.01) in the Pattern ComparisonTest. Regarding chronic exposure at residence, an IQR increment of PM2.5 exposure was associated withslower performances in the Continuous Performance (9.45 ± 3.47 msec; p = 0.007) and Stroop Tests (59.9 ±26.5 msec; p = 0.02). Similar results were obtained for PM10 exposure. In essence, we showed differential neurobehavioralchanges robustly and adversely associated with recent or chronic ambient exposure to PM air pollutionat residence, i.e., with recent exposure for visual information processing speed (Pattern Comparison Test)and with chronic exposure for sustained and selective attention This work was supported by the Research Foundation-Flanders (FWO, G073315N/G.0873.11.N10) and European Research Council (ERC-2012-StG 310898). Eline B. Provost has a VITO-FWO PhD fellowship. Karen Vrijens has a FWO postdoctoral fellowship (12D7714N). |
| Databáze: | OpenAIRE |
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