Faecal regenerating 1B protein concentration is not associated with child growth in rural Malawi
| Autor: | Yue-Mei Fan, Lotta Hallamaa, Kirsi-Maarit Lehto, Ulla Ashorn, Yin Bun Cheung, Zhifei Liu, Sami Oikarinen, Per Ashorn, Seppo Parkkila, Kenneth Maleta, Heikki Hyöty |
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| Přispěvatelé: | Tampere University, BioMediTech, Clinical Medicine, Department of Paediatrics, Department of Clinical Microbiology, Department of Clinical Chemistry |
| Rok vydání: | 2020 |
| Předmět: |
Male
Rural Population Malawi Veterinary medicine Longitudinal data Growth Feces 03 medical and health sciences 0302 clinical medicine Pregnancy 3123 Gynaecology and paediatrics 030225 pediatrics Secondary analysis Lithostathine Humans Medicine 030212 general & internal medicine Child growth Child Randomized Controlled Trials as Topic rural Malawi Anthropometry Anthropometric data business.industry Body Weight Infant Original Articles Body Height intestinal repair child growth Child Preschool Pediatrics Perinatology and Child Health regenerating 1B protein Original Article Female 3111 Biomedicine business Protein concentration |
| Zdroj: | Journal of Paediatrics and Child Health |
| ISSN: | 1440-1754 1034-4810 |
| Popis: | AIM: This study was designed to determine whether faecal regenerating 1B protein (REG1B) concentration is associated with physical growth among 6-30-month-old children in rural Malawi. METHODS: This was a secondary analysis from a randomised controlled trial in rural Malawi in which we followed-up 790 live-born infants from birth to 30 months of age. We collected anthropometric data at the age of 6, 12, 18, 24 and 30 months. We measured faecal REG1B concentration by enzyme-linked immunosorbent assay (ELISA) technique using stool samples collected at 6, 18 and 30 months of age. We assessed the association between faecal REG1B concentration and children's physical growth using linear regression and longitudinal data analysis. RESULTS: Of 790 live-born infants enrolled, 694 (87%) with at least one faecal REG1B concentration measurement were included in the analysis. Faecal REG1B concentration was not associated with the children's concurrent length-for-age z-score (LAZ), weight-for-age z-score (WAZ), weight-for-length z-score (WLZ) and mid-upper arm circumference-for-age z-score (MUACZ) at any time point (P > 0.05), nor with a change in their anthropometric indices in the subsequent 6-month period (P > 0.05). CONCLUSIONS: Faecal REG1B concentration is not associated with LAZ, WAZ, WLZ and MUACZ among 6-30-month-old infants and children in rural Malawi. publishedVersion |
| Databáze: | OpenAIRE |
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