Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets
| Autor: | Maria Rosa Chitolina Schetinger, Vera Maria Morsch, Daniela Zanini, Victor Camera Pimentel, Daniela B.R. Leal, Jessié Martins Gutierres, Juarez Chiesa, Andréia Machado Cardoso, Liliane Oliveira, Roberta Schmatz, Gustavo R. Thomé, Naiara Stefanello, Paula Acosta Maldonado |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Platelets
Male Adenosine monophosphate Lung Neoplasms Platelet Aggregation Antineoplastic Agents Pharmacology chemistry.chemical_compound Adenosine deaminase Carcinoma Non-Small-Cell Lung medicine Humans Aged Neoplasm Staging Aged 80 and over biology Nucleotides Chemistry Hydrolysis Cancer Nucleosides AMP deaminase General Medicine Middle Aged medicine.disease Molecular biology Adenosine Adenosine diphosphate Case-Control Studies biology.protein Thromboregulation Female Adenosine triphosphate medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 66:40-45 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2011.09.003 |
| Popis: | Background The nucleotides and nucleosides of adenine are signaling molecules related to thromboregulation and modulation of immune responses in patients with malignancies. Thus, this study aims to determine NTPDase, 5′-nucleotidase, ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in the platelets of patients with lung cancer. Methods We collected blood samples from patients ( n = 33) previously treated for lung cancer with chemotherapy. Patients were classified as stage IIIb and IV according to the Union for International Cancer Control (UICC). Results Patients showed a significant decrease in the hydrolysis of adenosine diphosphate (ADP) and adenosine, whereas the adenosine monophosphate (AMP) hydrolysis and platelet aggregation were significantly increased in this group. Adenosine triphosphate (ATP) hydrolysis did not show significant results between the group of patients and the control group. Conclusions We may suggest that ectonucleotidases as well as ADA are enzymes involved in thromboembolic events but especially here we may see that they are also directly involved in the generation of adenosine formation in the cancer patient circulation. |
| Databáze: | OpenAIRE |
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