Solvent-Switched Manganese(I)-Catalyzed Regiodivergent Distal vs Proximal C-H Alkylation of Imidazopyridine with Maleimide

Autor:	Tamanna Khandelia, Subhendu Ghosh, Bhisma K. Patel
Rok vydání:	2021
Předmět:	Imidazopyridine Metalation Organic Chemistry Alkylation Biochemistry Medicinal chemistry Solvent chemistry.chemical_compound chemistry Electrophile Chelation Physical and Theoretical Chemistry Maleimide Tetrahydrofuran
Zdroj:	Organic letters. 23(19)
ISSN:	1523-7052
Popis:	A sustainable Mn(I)-catalyzed exclusive solvent-dependent functionalization of imidazopyridine with maleimide via an electrophilic metalation at the distal (in 2,2,2-trifluoroethanol (TFE)) and chelation assisted at the proximal (in tetrahydrofuran (THF)) has been developed. The strategy was successfully applied to the drug Zolimidine and a broad range of substrates, thereby reflecting the method’s versatility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864f7ea89e0579890354c0c7ac82b9ac https://pubmed.ncbi.nlm.nih.gov/34543041 Zobrazit plný text záznamu