TREATMENT OF PERNICIOUS ANAEMIA WITH HOG'S STOMACH: REPORT OF 108 CASES
| Autor: | John F. Wilkinson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pathology biology Glossitis business.industry Stomach General Engineering General Medicine Articles medicine.disease Gastroenterology Pernicious anaemia Liver therapy medicine.anatomical_structure Pepsin Preliminary report Internal medicine medicine biology.protein General Earth and Planetary Sciences business General Environmental Science |
| Zdroj: | British medical journal. 1(3654) |
| ISSN: | 0007-1447 |
| Popis: | The successful results of some experiments upon the value of hog's stomach tissues in the treatment of pernicious anaemia were published in a preliminary report upon nine cases so treated in the laboratory.1 It was found that very good results could be obtained either with uncooked fresh hog's stomach tissues or desiccated preparations of the same. By using such active products in cases of pernicious anaemia remissions were initiated more quickly and progress was better maintained than with the liver treatment. Subjective symptoms, such as glossitis, par aesthesiae, and gastro-intestinal disturbances, were mucli more rapidly and satisfactorily relieved without the aid of the mixture of hydrochloric acid and pepsin so often necessary in liver therapy. In 1929 Sturgis, Isaacs, and Sharp,2 working independently along similar lines, reported remission in three cases, using a desiccated preparation. More recently they have made observations upon thirty nine cases of pernicious anaemia for periods up to ten weeks.3 These results have been confirmed by workers in other countries, but the number of cases reported has been few, while the periods of observation have not been sufficiently long to indicate the real value of this form of therapy. Conner4 has reported six cases and Rosenow5 two where similar treatment was employed for pernicious anaemia. Meulengracht and Hecht-Johansen6 obtained satisfactory responses using desiccated preparations, but failed to get an active extract (one case) according to Cohn's method with liver. Ungley7 also failed to produce remissions in two cases treated with fresh sheep's stomach. I have confirmed this result using the desiccated prepara tion. Five cases have been recorded by Snapper and Dupreez8 as having been successfully treated with hog's stomach, while Hitzenberger,9 Faber,10 Winge,11 and Lambin and Steenhoudt12 have also obtained satisfactory results in a smaller number of cases. |
| Databáze: | OpenAIRE |
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