Protective Effects of Mutant Ubiquitin in Transgenic Mice
| Autor: | M. Beyers, Maria Tsirigotis, John Woulfe, Jan Brun, Douglas A. Gray, Matthew Y. Tang, M. Zhang |
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| Rok vydání: | 2004 |
| Předmět: |
Genetically modified mouse
Aging Proteasome Endopeptidase Complex Time Factors Transgene Mutant Mice Transgenic General Biochemistry Genetics and Molecular Biology Body Temperature Mice History and Philosophy of Science Ubiquitin Multienzyme Complexes In vivo Animals Proteasome Pathway Genetics biology Life span General Neuroscience Body Weight Cell biology Cysteine Endopeptidases Retroviridae Mutation biology.protein Cisplatin DNA Damage |
| Zdroj: | Annals of the New York Academy of Sciences. 1019:215-218 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1196/annals.1297.035 |
| Popis: | The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging. |
| Databáze: | OpenAIRE |
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