Magnetic resonance imaging in locally advanced rectal cancer : quantitative evaluation of the complete response to neoadjuvant therapy
| Autor: | Nicola Tarallo, Genti Xhepa, Maria Gloria Angeretti, Fausto Sessa, Raffaele Novario, Chiara Tagliaferri, Valeria Molinelli, Paolo Antognoni, Carlo Fugazzola, Elena Bracchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer medicine.medical_treatment diffusion-weighted imaging chemoradiation therapy Locally advanced Chemoradiation therap Diffusion-weighted imaging Magnetic resonance imaging Rectal cancer Radiology Nuclear Medicine and Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear Medicine and Imaging Medicine magnetic resonance imaging In patient cardiovascular diseases rectal cancer Complete response Neoadjuvant therapy Chemotherapy Original Paper medicine.diagnostic_test business.industry medicine.disease 030220 oncology & carcinogenesis Radiology business Diffusion MRI |
| Zdroj: | Polish Journal of Radiology |
| Popis: | Purpose: To assess the diagnostic performance of diffusion-weighted imaging (DWI) for the discrimination of complete responder (CR) from the non-complete responder (n-CR) in patients with locally advanced rectal cancer (LARC) undergoing chemotherapy and radiation (CRT). Material and methods: Between December 2009 and January 2014, 32 patients (33 lesions: one patient had two synchronous lesions) were enrolled in this retrospective study. All patients underwent a pre- and post-CRT conventional MRI study completed with DWI. For both data sets (T2-weighted and DWI), the pre- and post-CRT tumour volume (VT2; VDWI) and the tumour volume reduction ratio (ΔV%) were determined as well as pre- and post-CRT apparent diffusion coefficient (ADC) and ADC change (ΔADC%). Histopathological findings were the standard of reference. Receiver operating characteristic (ROC) curves were generated to compare performance of T2-weighted and DWI volumetry, as well as ADC. Results: The area under the ROC curve (AUC) revealed a good accuracy of pre- and post-CRT values of VT2 (0.86; 0.91) and VDWI (0.82; 1.00) as well as those of ΔVT2% (0.84) and ΔVDWI% (1.00) for the CR assessment, with no statistical difference. The AUC of pre- and post-CRT ADC (0.53; 0.54) and that of ΔADC% (0.58) were significantly lower. Conclusions: Both post-CRT VDWI and ΔVDWI% (AUC = 1) are very accurate for the assessment of the CR, in spite of no significant differences in comparison to the conventional post-CRT VT2 (AUC = 0.91) and ΔVT2% (AUC = 0.84). On the contrary, both ADC and ΔADC% values are not reliable. |
| Databáze: | OpenAIRE |
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