Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis
| Autor: | Robert E. Schaub, Lawrence W. Torley, Arnold L. Oronsky, M L Carroll, Allan Wissner, Susan Quinn DeJoy, Suresh S. Kerwar, Constance Kohler, Walter C. Pickett |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Gram-negative bacteria medicine.medical_treatment Blood Pressure Biology Pharmacology Permeability Mice chemistry.chemical_compound Organophosphorus Compounds medicine Animals Humans Pharmacology (medical) Platelet Activating Factor Rats Wistar Interleukin 6 Mice Inbred BALB C Mice Inbred ICR Chemotherapy Platelet-activating factor Interleukin-6 Tumor Necrosis Factor-alpha Antagonist biology.organism_classification Rats Bacterial sepsis Macaca fascicularis Thiazoles Infectious Diseases Blood pressure chemistry Immunology biology.protein Female Tumor necrosis factor alpha Rabbits Hypotension Gram-Negative Bacterial Infections Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 36:1971-1977 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.36.9.1971 |
| Popis: | The effect of CL 184,005, a potent and specific platelet-activating factor antagonist, has been examined in a variety of animal models relevant to gram-negative bacterial sepsis. Pretreatment of mice with CL 184,005 protected them from the lethal effects of platelet-activating factor. When rats or primates rendered hypotensive with endotoxin were treated with CL 184,005, blood pressure was normalized. Pretreatment of rats with CL 184,005 protected them from the gastrointestinal lesions induced by endotoxin. Pretreatment of rats and mice with CL 184,005 protected them from the lethal effects of endotoxin. Plasma tumor necrosis factor levels in endotoxin-treated mice were lower when the mice were pretreated with CL 184,005. These observations suggest that CL 184,005 may be potentially useful in the treatment of gram-negative bacterial sepsis, and the agent is undergoing clinical evaluation. |
| Databáze: | OpenAIRE |
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