Laboratory studies after intrathecal corticosteroids: determination of corticosteroids in plasma and cerebrospinal fluid
| Autor: | Devina C. Tweed, Arjun D. Sehgal, Mary K. Foote, W. James Gardner |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
business.industry
medicine.medical_treatment Research Laminectomy Methylprednisolone acetate Intrathecal medicine.disease Methylprednisolone Lumbar medicine.anatomical_structure Cerebrospinal fluid Arts and Humanities (miscellaneous) Adrenal Cortex Hormones Anesthesia medicine Humans Neurology (clinical) Subarachnoid space Arachnoiditis business medicine.drug Cerebrospinal Fluid |
| Zdroj: | Archives of neurology. 9 |
| ISSN: | 0003-9942 |
| Popis: | Introduction Methylprednisolone acetate * has been administered intrathecally in more than 1,000 patients for the treatment of neurologic disorders 1-3 during the last three years. The treatment has proved safe, and the results are encouraging. It has become a standard method of treatment for arachnoiditis resulting from trauma, Pantopaque, or laminectomy. With this new method of administration we thought it expedient to ascertain: first, how long methylprednisolone acetate remains in the cerebrospinal fluid after intrathecal administration; secondly, whether methylprednisolone acetate injected at the lumbar level is dispersed evenly throughout the subarachnoid space, or remains in a higher concentration at the site of injection, by analyzing fluids obtained simultaneously at lumbar and cisternal punctures; thirdly, the duration of action of the steroid as judged by the effect on endogenous secretion of corticosteroids; fourthly, the effect on spinal fluid pressure, protein and cell content of various amounts of methylprednisolone acetate. Methods, Procedures, and |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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