DNT Cell-based Immunotherapy: Progress and Applications
| Autor: | Jun Xie, Xueke Fan, Miao Wang, Qin Li, Songtao Fu, Yingrui Li, Kang Dong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
DNTs
tumor medicine.medical_treatment CD3 Review 01 natural sciences 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Immunity medicine biology 010405 organic chemistry Effector business.industry Cancer Immunotherapy medicine.disease In vitro 0104 chemical sciences Oncology 030220 oncology & carcinogenesis biology.protein Cancer research immunotherapy business |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.39717 |
| Popis: | Cancer immunotherapy has firmly established a dominant status in recent years. Adoptive cellular immunotherapy (ACI) is the main branch of immunotherapy. Recently, the immune effector cells of ACI, such as T cells, NK cells, and genetically engineered cells, have been used to achieve significant clinical benefits in the treatment of malignant tumors. However, the clinical applications have limitations, including toxicity, unexpectedly low efficiency, high costs and strict technical requirements. More exploration is needed to optimize ACI for cancer patients. CD3+CD4-CD8- double negative T cells (DNTs) have emerged as functional antitumor effector cells, according to the definition of adoptive immunotherapy. They constitute a kind of T cell subset that mediates nontumor antigen-restricted immunity and has important immune regulatory functions. Preclinical experiments showed that DNTs had a dual effect by killing tumor cells and inhibiting graft-versus-host disease. Notably, DNTs can be acquired from healthy donors and expanded in vitro; thus, allogeneic DNTs may be provided as “off-the-shelf” cellular products that can be readily available for direct clinical application. We review the progress and application of DNTs in immunotherapy. DNTs may provide some novel perspectives on cancer immunotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|