Small Lymphocytic Lymphoma: Analysis of Two Cohorts Including Patients in Clinical Trials of the German Chronic Lymphocytic Leukemia Study Group (GCLLSG) or in 'Real-Life' Outside of Clinical Trials
| Autor: | Kirsten Fischer, Theodoros P. Vassilakopoulos, Barbara Eichhorst, Vassiliki Bartzi, Efstathios Koulieris, Michael Hallek, Pantelis Tsirkinidis, Xanthi Yiakoumis, Georgia Levidou, Anna-Maria Fink, Jasmin Bahlo, Christina Kalpadakis, Marie-Christine Kyrtsonis, Maria K. Angelopoulou, Gerassimos A. Pangalis, Maria Moschogiannis, Sotirios Sachanas |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Chronic lymphocytic leukemia Lymphocytic lymphoma Disease-Free Survival Internal medicine Germany medicine In real life Humans Lymph node Therapeutic strategy Aged Cell Proliferation Clinical Trials as Topic business.industry General Medicine Middle Aged medicine.disease Prognosis Leukemia Lymphocytic Chronic B-Cell Lymphoma Fludarabine Clinical trial medicine.anatomical_structure Female Lymph Nodes business medicine.drug |
| Zdroj: | Anticancer research. 39(5) |
| ISSN: | 1791-7530 |
| Popis: | Background: Only few studies have focused exclusively on patients with small lymphocytic lymphoma (SLL). Patients and Methods: In the present report, 103 SLL patients were analyzed from both, clinical trials of the German Chronic Lymphocytic Leukemia Study Group and Greek centers, and emphasis was placed on the therapeutic strategy. The impact of lymph node characteristics, such as the presence of proliferation centers (PCs) on response and survival was also assessed. Results: SLL patients included in clinical trials were treated mostly with fludarabine-based regimens while those in reallife were staged and treated mostly as patients with low-grade lymphomas. Our analysis showed a trend for better survival for patients with SLL without detectable PCs. Conclusion: Patients with SLL outside of clinical trials are usually treated as cases of lymphoma. In addition, this analysis supports published data regarding the adverse prognostic value of the presence of PCs in lymphoid nodes in SLL. |
| Databáze: | OpenAIRE |
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