Domino hepatic transplantation using the liver from a patient with primary hyperoxaluria
| Autor: | El Nakadi I, Michel Gelin, Hubert Louis, Brigitte Ickx, Donckier, Jean Closset, Michael Adler, Nadine Bourgeois, Le Moine O |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis Tissue and Organ Procurement medicine.medical_treatment Liver transplantation Gastroenterology Domino Primary hyperoxaluria Internal medicine medicine Cadaver Humans Aged Hepatitis Transplantation Hyperoxaluria business.industry Liver and kidney medicine.disease Surgery Liver Transplantation surgical procedures operative Liver Hepatocellular carcinoma Tissue and Organ Harvesting business |
| Zdroj: | Transplantation. 71(9) |
| ISSN: | 0041-1337 |
| Popis: | Background. We report a case of domino liver transplantation using the liver harvested from a patient who underwent a combined liver and kidney transplantation for primary hyperoxaluria (PH). Method. A cadaveric liver transplantation was performed in a 19-year-old man with PH. In a second step, the PH liver harvested from the first patient was transplanted in a 69-year-old man with hepatitis C-related cirrhosis, not a candidate for a classic liver graft owing to multifocal hepatocellular carcinoma. Results. At 8 months after transplantation, the domino recipient has normal hepatic function and no signs of tumoral recurrence, but he progressively developed hyperoxalemia, hyperoxaluria, and renal insufficiency. Conclusion. Regarding the favorable postoperative clinical evolution, domino liver transplantations using livers from PH patients may represent a new opportunity for marginal candidates for liver transplantation. However, the progressive renal insufficiency expected in such domino recipients should limit this procedure to selected cases. |
| Databáze: | OpenAIRE |
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