Ceftazidime versus ceftazidime plus tobramycin in febrile neutropenic children
| Autor: | D L Becton, Subhash Chaudhary, K A Pappa, T S Vats, M Kletzel, R F Jacobs |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Neutropenia Combination therapy Adolescent Fever medicine.drug_class medicine.medical_treatment Antibiotics Ceftazidime Antineoplastic Agents Pharmacotherapy Internal medicine medicine Tobramycin Humans Child Chemotherapy business.industry Aminoglycoside Infant Drug Resistance Microbial General Medicine Bacterial Infections medicine.disease Infectious Diseases Treatment Outcome Anesthesia Child Preschool Superinfection Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Infection. 21(4) |
| ISSN: | 0300-8126 |
| Popis: | Although the effectiveness of antibiotic monotherapy in febrile neutropenic patients remains unproven, ceftazidime has been shown previously to be effective monotherapy for the empiric treatment of selective patients. The efficacy and safety of ceftazidime versus ceftazidime plus tobramycin was evaluated in the treatment of febrile children (range 8 months to 18 years) with neutropenia secondary to cancer chemotherapeutic agents. Of the evaluable 89 patients, 45 received ceftazidime and 44 received ceftazidime plus tobramycin for 5 to 10 days. At the end of therapy, 30 (67%) of the 45 ceftazidime-treated patients were clinically cured compared with 38 (86%) of 44 combination-treated patients. Thirteen (29%) of the patients treated with ceftazidime failed to respond clinically to treatment, versus four (9%) of the patients treated with ceftazidime/tobramycin (p = 0.046). This study suggests that ceftazidime as monotherapy in febrile neutropenic children may be inferior to combination therapy for optimal clinical response in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink